![]() ![]() We plan to generate tailored chimeric antigen receptor (CAR) NK cells with an NKG2D-CAR at their surface. Due to the re-expression of NKG2DL on their surface, LSCs become targetable by the immune system. ![]() Genetic or pharmacologic inhibition of PARP1 induces NKG2DLs specifically on LSCs but not on healthy or pre-leukemic cells.
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